Contact Us

  • Faculty of Arts & Sciences
    Biology Department
    Pamukkale University
    Denizli 20070

  • Phone :
    +90 (0) 258 296 3574
  • Email :sena@pau.edu.tr

SCI Papers

  1. Yavuz, S., Çetin, A., Akdemir, A., Doyduk, D., Dişli, A., Çelik Turgut, G., Şen, A., Yıldırır, Y (2017) Synthesis and Functional Investigations of Computer Designed Novel Cladribine-Like Compounds for the Treatment of Multiple Sclerosis. Archiv der Pharmazie 350(11): 1700185. DOI: 10.1002/ardp.201700185

  2. Semiz, A., Celik-Turgut, G., Karakurt, S., Akca, H., Arslan, S., Adali, O., Sen, A. (2017) In vivo examination of the effects of hydroxycinnamic acid on xenobiotic metabolizing and antioxidant enzymes. Archives of Biological Sciences 69(1): 103-110. DOI: 10.2298/ABS160208083S

  3. Turgut, G.Ç., Doyduk, D., Yıldırır, Y., Yavuz, S., Akdemir, A., Dişli, A., Şen, A. (2017) Computer design, synthesis, and bioactivity analyses of drugs like fingolimod used in the treatment of multiple sclerosis. Bioorganic and Medicinal Chemistry 25(2): 483-495. DOI: 10.1016/j.bmc.2016.11.015

  4. Ozgun-Acar, O., Gazioglu, I., Kolak, U., Sen, A., Topcu, G. (2017) A potential therapeutic role in multiple sclerosis for stigmast-5,22-dien-3β-olmyristate isolated from Capparis ovata. The EuroBiotech Journal 1: 241-246. DOI: 10.24190/ISSN2564-615X/2017/03.08

  5. Ozden Ozgun-Acar, Gurbet Celik-Turgut, Isil Gazioglu, Ufuk Kolak, Seda Ozbal, Bekir U. Ergur, Sevki Arslan, Alaattin Sen*, Gulacti Topcu (2016) Capparis ovata treatment suppresses inflammatory cytokine expression and ameliorates experimental allergic encephalomyelitis model of multiple sclerosis in C57BL/6 mice. Journal of Neuroimmunology 298: 106–116. dx.doi.org/10.1016/j.jneuroim.2016.07.010

  6. Özakin, S., Davis, R.W., Umile, T.P., Pirinccioglu, N., Kizil, M., Celik, G., Sen, A., Minbiole, K.P.C., İnce, E. (2016) The isolation of tetrangomycin from terrestrial Streptomyces sp. CAH29: evaluation of antioxidant, anticancer, and anti-MRSA activity. Medicinal Chemistry Research 25(12): 2872-2881.

  7. A. Semiz, G. Çelik-Turgut, G. Semiz, Ö. Özgün and A. Şen (2016) Association between herbivore stress and glutathione S-transferase expression in Pinus brutia Ten. Cellular and Molecular Biology 62(3): 89-94. doi: 10.14715/cmb/2016.62.3.15

  8. Gurbet CELIK, Asli SEMIZ, Serdar KARAKURT, Sevki ARSLAN, Orhan ADALI and Alaattin SEN (2016) Ellagic Acid Content Contribute to the Inhibitory Action of Epilobium hirsutum on Drug Metabolizing Enzymes. European Journal of Drug Metabolism and Pharmacokinetics 41(2):109-116 (doi: 10.1007/s13318-014-0238-1)

  9. Serdar Karakurt, Gurbet Celik, Ayşe Mine Gencler-Ozkan, Aslı Semiz, Alaattin Sen, Orhan Adali (2014) Contribution of Ellagic Acid on the Antioxidant Potential of Medicinal Plant Epilobium hirsutum. Nutrition and Cancer: An International Journal 68(1): 173-183. doi:10.1080/01635581.2016.1115092

  10. Tugba Boyunegmez Tumer, Seda Savranoglu, Pelin Atmaca, Gulsum Terzioglu, Alaattin Sen, Sevki Arslan (2016) Modulatory Role of GSTM1 Null Genotype on Micronucleus Frequency in Pesticide Exposed Agricultural Workers. Toxicology and Industrial Health 32(12): 1942-1951. doi: 10.1177/0748233715599876

  11. Asli Semiz, Gurbet Celik-Turgut, Serdar Karakurt, Hakan Akca, Sevki Arslan, Orhan Adali and Alaattin Sen In Vivo Examination of the Effects of Hydroxycinnamic Acid on Xenobiotic Metabolizing and Antioxidant Enzymes. Arcieves of Biological Sciences (In Press)

  12. Adile SARI, Mustafa DURAN, Alaattin SEN, Fevzi BARDAKCI (2015) Investigation of Chironomidae (Diptera) relationships using mitochondrial COI gene. Biochemical Systematics and Ecology 59: 229-238. (DOI: 10.1016/j.bse.2015.01.005)

  13. Semiz, A. and Sen A. (2015) Cloning and expression of a CYP720B orthologue involved in the biosynthesis of diterpene resin acids in Pinus brutia. Molecular Biology Reports 42(3): 737-744. (DOI: 10.1007/s11033-014-3822-1)

  14. Arslan, S., Terzioglu, G., Atmaca, P., Celik, G., Ozgun, O. and Sen, A. (2015) Carcinogen Activating and Drug Interaction Potential of o-Coumaric Acid. Pharmaceutical Biology , April 16, 2015, 1-8, (DOI:10.3109/13880209.2015.1014919)

  15. Sen, Alaattin., Atmaca, Pelin., Terzioglu, Gulsum., Arslan, Sevki. (2013) Anticarcinogenic effect and carcinogenic potential of the dietary phenolic acid: o-Coumaric acid. Natural Product Communications 8(9): 1269-1274.

  16. Celik, G., Semiz, A., Karakurt, S., Arslan, S., Adali, O., and Sen, A. (2013) A Comparative Study for the Evaluation of Two Doses of Ellagic Acid on Hepatic Drug Metabolizing and Antioxidant Enzymes in the Rat.BioMed Research International BioMed Research International 2013 , art. no. 358945. http://dx.doi.org/10.1155/2013/358945

  17. Karakurt, S., Semiz, A., Çelik, G., Gencler-Özkan A.M., Sen, A., Adalı, O. Epilobium hirsutum alters xenobiotic metabolizing CYP1A1, CYP2E1, NQO1 and GPx activites, mRNA and protein levels in rats. Pharm Biol, 2013; 51(5): 650–658. 

  18. Celik G., Akca H., Sen A. Investigation of aromotase inhibitor activities in several dietary vegetables on human non–small cell lung cancer cell lines. Turkish Journal Biochemistry 2013; 38 (2) ; 207–217

  19. Alaattin Sen, Ozden Ozgun, Emel Arinc and Sevki Arslan (2012) Diverse action of acrylamide on cytochrome P450 and glutathione S-transferase isozyme activities, mRNA levels and protein levels in human hepatocarcinoma cells. Cell Biol. Toxicol. 28:175-186.

  20. Ozgen Buyukgoze, Necla Osmanoglu, Sevki Arslan, Alaattin Sen (2012)Association of the CYP1A1*2A, GSTT1 null, GSTM1 null, mEPHX*3, and XRCC1-399 genetic polymorphisms with ulcerative colitis. International Journal of Colorectal Disease DOI:10.1007/s00384-012-1507-6

  21. Begum Tutuncu, Vural Kucukatay, Şevki Arslan, Barbaros Sahin, Asli Semiz and Alaattin Sen (2012)Alteration of drug metabolizing enzymes in sulphite oxidase deficiency. Journal of Clinical Biochemistry and Nutrition 51(1):50-4. DOI:10.3164/jcbn.11-79

  22. Paraskeva Michailova, Julia Ilkova, Mustafa Duran, Erdal Karadurmus, Ridvan Berber & Alaatin Sen (2012): Structural and functional alterations in salivary gland chromosomes and enzyme activity of Chironomus riparius Mg. (Diptera, Chironomidae) from anthropogenically polluted sites in Bulgaria and Turkey, Caryologia: International Journal of Cytology, Cytosystematics and Cytogenetics, 65:2, 157-169

  23. Mustafa Duran, Paraskeva Michailova, Adile Sari, Julia Ilkova, Erdal Karadurmus, Alaatin Sen (2012) Assessment of the Sediment Toxicity in Bulgarian  and Turkish Rivers Using the Biomarkers in Chironomus riparius Mg. (Diptera: Chironomidae). Acta Zool. Bulg., Suppl. 4: 167-173

  24. Sevki ARSLAN, Ozden OZGUN, Gurbet CELIK, Asli SEMIZ, Olcay DUSEN, Ramazan MAMMADOV and Alaattin SEN (2011) Effects of Cyclamen trochopteranthum on Hepatic Drug Metabolizing Enzymes. Arch. Biol. Sci., Belgrade63 (3): 545-555.

  25. Adile Ozdemir, Mustafa Duran, Alaattin Sen (2011)Potential Use of the Oligochaete Limnodrilus profundicola V.,as a Bioindicator of Contaminant Exposure. Environ. Tox. 26(1):37-44. 

  26. Ardag Akdogan H, Ozel MZ, Sen A (2011) Polycyclic Aromatic Hydrocarbons in Water from the Menderes River, Turkey. Bulletin of Environmental Contamination and Toxicology 86:221-225.

  27. Hatice Ardağ Akdogan and Alaattin Sen (2010)Characterization of aging of drug metabolizing enzymes and assessment of aging in Gilthead Seabream (Sparus aurata) liver. Veterinarni Medicina 55(9); 463-471.

  28. Alaattin Sen, Onur Kenan Ulutas, Begum Tutuncu, Nusret Ertas, Ismet Cok (2010) Determination of 7-ethoxyresorufin-o-deethylase (EROD) induction in leaping mullet (Liza saliens) from the highly contaminated Aliaga Bay, Turkey. Environ Monit Assess 165 (1-4), 87-96.   

  29. Adile Ozdemir, Mustafa Duran, Gurcay Kivanc Akyildiz, Alaattin Sen (2010) EROD and Metallothionein in Limnodrilus profundicola (Oligochaeta: Tubificidae) as an indicator of pollution exposure in the Curuksu Stream of Menderes River, Denizli – TURKEY. Desalination and Water Treatment 26:98-103.

  30. Hizlan H. Agus, Pelin Tekin, Merve Bayav, Asli Semiz and Alaattin Sen (2009) Drug interaction potential of the seed extract of Urtica urens L. (dwarf nettle). Phytotherapy Research, 23(12), 1763-70.

  31. Michailova P., Sen A., Ilkova J., Berber R., Karadurmus E. and Duran M. (2010) Response at different levels of the genome of Chironomus riparius Mg. (Diptera, Chironomidae) collected from polluted rivers in Bulgaria and Turkeypreliminary results. Genetics and Breeding, 38:28-39.

  32. Ozkarsli M., Sevim H., and Şen A. (2008). In vivo effects of Urtica urens on the expression of CYP1A in control and 3-methylcholanthrene-exposed rats. Xenobiotica 38, 48-61.

  33. Şen A. and Semiz, A. (2007) Effects of Metals and Detergents on Biotransformation and Detoxification Enzymes of Leaping Mullet (Liza saliens). Ecotoxicology & Environmental Safety 68(3), 405-411.

  34. Semiz A. and Şen A. (2007) Antioxidant and chemoprotective properties of Momordica charantia L. (bitter melon) fruit extract. African Journal of Biotechnology 6, 273-277.

  35. Chung, W.-G., Şen, A., Wang-Buhler, J.-L.,  Yang, Y.-H., Lopez, N., Merrill, G. F., Miranda, C. L., Hu, C.-H., Buhler, D. R. (2004) cDNA-directed expression of a functional zebrafish CYP1A in yeast.  Aquatic Tox. 70, 111-121.

  36. Şen, A. and Kirikbakan, A. (2004) Biochemical Characterization and Distribution of Glutathione S-Transferases in Leaping Mullet (Liza Saliens). Biochem (Moscow) 69 (9), 993-1000.

  37. Akdogan, A., Deniz, M., Cebecioglu, S., Şen, A. And Deligöz, H. (2002) Liquid-liquid extraction of transition metal cations by nine new azo derivative calix]n]arene. Sep. Sci. Tech. 37, 973-980.

  38. Lee, S.-J., Hedstrom, O. R., Fisher, K., Wang-Buhler, J. L., Şen, A., Cok, I., and Buhler, D. R. (2001) Immunohistochemical localization and differential expression of cytochrome P450 3A27 in the gastrointestinal tract of rainbow trout. Tox. App. Pharmacol . 177, 94-102.

  39. Şen, A., Hu, C.-H., Urbach, E., Wang-Buhler, J-L., Yang, Y-H., Arınç, E., and Buhler, D. R. (2001) Cloning, sequencing and characterization of CYP1A1 cDNA from leaping mullet (Liza saliens) liver and implications for the potential functions of its conserved amino acids. J. Biochem. Mol. Toxicol. 15, 243-255

  40. Arınç, E., Şen, A., and Bozcaarmutlu A.(2000) Cytochrome P4501A (CYP1A) and Associated MFO Induction in Fish as a Biomarker for Toxic Carcinogenic Pollutants in the Aquatic Environment. Pure Appl. Chem 72, 985-994. 

  41. Şen, A., and Arınç, E. (2000) Further immunochemical and biocatalytic characterization of CYP1A1 from feral leaping mullet liver (Liza saliens) microsomes. Comp. Biochem. Physiol. 126C, 235-244.

  42. Arınç E. and Şen, A. (1999) Hepatic Cytochrome P4501A1 and 7-ethoxyresorufin O-deethylase induction in mullet and common sole as an indicator of toxic organic pollution in İzmir Bay, Turkey. Mar. Environ. Res. 48, 147-160.

  43. Şen, A., and Arınç, E. (1998) Purification and characterization of NADPH-cytochrome P450 reductase from feral Liza saliens liver microsomes. J. Biochem. Mol. Toxicol. 12, 103-113.

  44. Şen, A., and Arınç, E. (1998) Preparation of highly purified cytochrome P4501A1 from leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular and immunochemical properties. Comp. Biochem. Physiol Part C. 121, 249-265.

  45. Şen, A., and Arınç, E. (1997) Separation of three P450 isozymes from liver microsomes of gilthead seabream treated with b-NF and partial purification of cytochrome P4501A1. Biochem. Molec. Biol. Int. 41, 131-141.

  46. Arınç, E., Hanukoglu, I., Şen, A., and Adali, O. (1995) Tissue- and species dependent expression of sheep lung microsomal cytochrome P4502B(LgM2). Biochem. Molec. Biol. Int. 37, 1121-1126.

  47. Arınç, E., and Şen, A. (1994) In vivo effects of  anesthetic, benzocaine, on liver microsomal cytochrome P450 and mixed-function oxidase activities of gilthead seabream (Sparus aurata).  Comp.  Biochem.  Physiol.107C, 399-404.

  48. Arınç, E., and Şen, A. (1994) Effects of in vivo  benzo(a)pyrene treatment on liver microsomal mixed-function oxidase activities of gilthead seabream (Sparus aurata). Comp.  Biochem.  Physiol. 107C, 405-414.

  49. Arınç, E., and Şen, A. (1993) Effects of in vivo  benzene treatment on cytochrome P450 and mixed-function oxidase activities of gilthead seabream.  Comp. Biochem. Physiol. 104C, 61-66.

  50. Arınç, E., and Şen, A. (1993) Characterization of cytochrome P450 dependent mixed-function oxidase system in gilthead seabream (Sparus aurata; Sparidae) liver. Comp. Biochem. Physiol. 104B, 133-139.